Hemoglobin And Sickle Cell Disease - 1793 Words

Ana-Maria Sutac Biochemistry 370 11/13/2015 Hemoglobin and Sickle Cell Disease Introduction Sickle cell disease, also known as SCD, is a hereditary blood disorder that takes place due to mutation in the hemoglobin gene that is found in red blood cells. While it is said to have originated in Africa and is mostly predominant in African Americans, sickle cell disease is now common among different ethnic groups all over the world. Sickle cell anemia (HbSS) infects â€Å"an estimated 70,000 to 100,000 Americans†(Housman) and accounts for approximately 70% of anemia in the United States. Hemoglobin functions as an oxygen carrying protein as it carries oxygen from the lungs through the arteries and to the rest of the body. In sickle cell disease,†¦show more content†¦These subunits are held together by ionic, hydrogen bonds, van der Waals forces, hydrophobic interactions as well as heme groups that are made up of Fe2+. Hemoglobin can be found in two different states. The first state is known as the T-state when it is tense and oxygen deprived. The second state is known as R-state when is relaxed and oxygenated. Hemoglobin first binds to oxygen then transports it to blood vessels, which have low oxygen levels. After it releases the oxygen the blood vessels, the red cells then transports carbon dioxide (CO2) from the tissues to the lungs where it picks oxygen once more. Cooperativiy, Affinity, and Efficiency When a subunit binds to oxygen, it changes it conformation and sends messages to other subunits to bind to oxygen as well. When more hemoglobin monomers (subunits) bind to oxygen, it is increasing hemoglobin’s affinity to oxygen, thus leading to better cooperativity. It was also discovered that there is a higher affinity for purified hemoglobin rather than the hemoglobin inside the red blood cells due to the anionic compound 2,3-bisphosphoglycerate (2,3-BPG). This molecule binds to hemoglobin in a small pocket only found in the T state when it is deoxygenized and allows it become stable. It further causes a reduction in hemoglobin’s affinity to oxygen, working out in its favor. During the transition from T to R state, the pocket containing 2,3-BPG is broken and

Illinois Wesleyan University GPA, SAT ACT Score Data

Transcendentalism In Chris Krakauers Into The Wild

Transcendentalism by definition means to live a rational life with nature and becoming one entity that rules over itself. That seems difficult though because living in this day an age without having to worry about anything or about anyone else is like asking for forever lasting gum. In the book Into The Wild, Chris McCandless tries to do just that and succeeds. While on his journey to Alaska, Chris becomes the embodiment of transcendentalism. He embraces multiply of the qualities of transcendentalism but there were three that were the most prominent throughout the story. He believed in living closer to nature, relied on self trust and self reliance, and also he insists on breaking from traditions like government or paying taxes like most†¦show more content†¦While in these different states he met people along the way that got close to him and wanted to help him on his journey. He believed in self reliance and self trust so whenever people offered him anything he wouldnâ€⠄¢t take them. (Krakauer 33). After an extended argument Burress also got McCandless to accept some long underwear and other warm clothing she thought he would need in Alaska. â€Å"He eventually took it to shut me up.† said Burres. â€Å"But the day after I found most of it in the van.† It is quite obvious that Chris did not want to help of others or rather even hated it. (Krakauer 33). As the novel states Chris â€Å"Acted really offended when Burres offered him supplies.† Chris hated when he was offered help most likely because he wanted to be able to prove something that he could do this odessey without anyone’s help. He left the people that he met with the impression that he didn’t want their help although he liked their company. As well as the fact that he was determined to accomplish his goals by all means necessary. Lastly Chris McCandless wanted to break from the normal life of obeying laws and paying taxes. He wanted to become his own en tity, one that had control over itself and that is it. He didn’t need laws or taxes where he was going. He was going to live off the land and never go back to the stressful life that most adults in America live. Chris also did not like the government at all. (Krakauer 06). â€Å"Hell, no. How I feed myself isShow MoreRelatedRalph Waldo Emersons Nature Analysis708 Words   |  3 Pagesin the sunshine. Swim in the sea. Drink the wild air† -Ralph Waldo Emerson. Emersons quote enlightens the idea of transcendentalism. Declaring to enjoy nature for what it is , to value the idea of having the freedom of it and to realize there is more to life than what you are living. In the essay, â€Å"Nature†, by Ralph Waldo Emerson he finds himself challenged by the honesty of nature, which compares to Chris McCandless adventure in the book, Into the Wild, by Jon Krakauer. First, one must enjoy thingsRead MoreChris Mccandless Was Different From Other People. His Ideas1484 Words   |  6 PagesChris McCandless was different from other people. His ideas were perceived as strange from the outside eye. Was McCandless crazy or was he simply misunderstood? Everyone has their own opinion on this question including Shaun Callarman. He believes Chris is â€Å" just plain crazy,† however there is no hard evidence that proves this statement or completely backs it up. Callarman says I think that Chris McCandless was bright and ignorant at the same time. He had no common sense, and he had no businessRead MoreChristopher McCandless: Rebellious, Suicidal Narcissist1570 Words   |  6 Pages Transcendentalism is a religious, philosophical, literary, and social movement of the nineteenth century. Essentially, this movement was based upon the ideals of the â€Å"sixth sense,† nature, and non-conformity, as well as individualism, intuition, idealism, imagination, and inspiration. A few of the works featured in the transcendental unit include Into the Wild by Jon Krakauer, Song of Myself by Walt Whitman, and Walden by Ralph Waldo Emerson. The primary focus of this essay is to provide an opinionRead MoreChris McCandless, Henry David Thoreau and Ralph Waldo Emerson1205 Words   |  5 Pages Chris McCandless: a man so infatuated with nature, he practically committed suicide to bring himself nearer to it. This extreme liking for nature, along with other ideals, makes up the core tenets of the transcendentalist philosophy. McCandless demonstrates other tenets of transcendentalism as well, most notably the supremacy of the individual, by detaching himself from the mammon o f this world. Another way he shows the supremacy of the individual, by the belief that one should not conform to theRead MoreThe Crucible Opinion Paper812 Words   |  4 Pagesmind? Reckless? Young? Naà ¯ve? Gullible? Into the Wild, by Jon Krakauer, is a book written about an extraordinary but childlike man who set out on a quest, looking for an adventure of being surrounded by nature. Chris McCandless, who the book is based off of, was a man of wonder. No one was ever certain about what he thought, how he felt, or why he went on this suicide journey. Was it because of his childlike recklessness? Or was it something deeper? Chris McCandless was reckless and along with that cameRead MoreTranscendentalist Mccandless Essay1021 Words   |  5 PagesTranscendentalist McCandless What is transcendentalism? How is Christopher J. McCandless a transcendentalist? Transcendentalism is a philosophy, and a way of life. It consists of being a non-conformist, becoming one with nature, and rejecting materialism. Throughout Jon Krakauer’s novel, Into The Wild, McCandless happens to achieve all of the above. â€Å"Whoso would be a man, must be a non-conformist† (Emerson). He defied society, lived in the wild, and never cared about â€Å"things†. He existedRead MoreThe Five Is of of Transcendentalism in the Modern Day1187 Words   |  5 PagesTimes, teenagers listen to an average of 2.5 hours of music in a singular day. The messages coming through in each song may vary between drug/alcohol reference or transcendentalism. No matter where there is music, there is a lesson to be learned through ideas that Ralph Waldo Emerson and Henry David Thoreau created. Though transcendentalism is a relatively foreign word to most, it can be defined by using five is: individualism, inspiration, intuition, idealism and imagination which are displayed onRead MoreAnalysis Of David Thoreau s Walden 1507 Words   |  7 PagesInterior Chris McCandless admired Henry David Thoreau, author of â€Å"Walden,† and adopted many of his ideals as his own. McCandless sought for simplicity and desired to stray from social norms and clichà © material goods. Although Thoreau’s book was found in Chris’ trailer, he did not live step by step how Thoreau did. He ventured beyond these transcendentalist ideals, taking them to unheard of heights. While Thoreau sought a life in the wilderness to ponder both nature and the world (â€Å"Walden†), Chris wentRead MoreMccandless Vs Transcendentalism1840 Words   |  8 Pagesopposite. This small group of individuals dedicates their lives to living outside of social norms and opposing others’ instructions of how to live their lives. They are known to many as transcendentalists. Both Chris McCandless and Timothy Treadwell lived lives that exemplified transcendentalism. Both men ultimately devoted their lives to reconnecting with nature. Both Treadwell and McCandless were transcendentalists, took up alter egos, left their families behind, naturally excelled at athletics in

Kevin Brown from the Radio Free free essay sample

Part 1 of 1 15.0 Points Question 1 of 10 1.5 Points According to John Locke, sounds, colors, temperatures, tastes, and odors are what type of quality? A.primary Correct B.secondary C.sensation D.reflection Answer Key: B Question 2 of 10 1.5 Points According to Kevin Brown from the Radio Free Philosophy Podcast, Locke held that all we have direct contact with are what? A.Objects of reality B.Ideas C.Words themselves D.Things in themselves Incorrect E.All of the above Answer Key: B Question 3 of 10 1.5 Points What, according to John Locke, are the two kinds of ideas that furnish the empty room of the mind? A.primary / secondary Correct B.sensation / reflection C.real / artificial D.none of the above Answer Key: B Question 4 of 10 1.5 Points According to John Locke, primary qualities of an object are what? A.innate ideas to the mind B.intrinsic features of objects of reality C.dependent on an observer Incorrect D.none of the above Answer Key: B Question 5 of 10 1.5 Points According to Empiricists the mind at birth†¦ A.has innate ideas B.is a reincarnated soul C.contains the Forms of the Good Correct D.is a blank slate Answer Key: D Question 6 of 10 1.5 Points What is the fundamental principle according to Locke’s empiricism? A.All knowledge begins with doubt. B.All knowledge arise from sense experience. C.All knowledge is a grasp for power. D.All knowledge is merely agreed upon opinion. Incorrect E.None of the above Answer Key: B Question 7 of 10 1.5 Points According to Immanuel Kant, we can never know what? Incorrect A.our experiences B.zombies C.the things in themselves D.cognitive categories of understanding Answer Key: C Question 8 of 10 1.5 Points According to John Locke, secondary qualities of an object have what? A.Qualities in the thing itself. B.The power to produce in us the ideas of sensation. Incorrect C.Features inseparable from the thing itself. D.The power to produce in us reflection on the objects inherent feature Answer Key: B Question 9 of 10 1.5 Points What is NOT a principle accepted by John Locke nor the other empiricists? Incorrect A.experience B.mathematics C.innate ideas D.all of the above Answer Key: C Question 10 of 10 1.5 Points Using Kant’s epistemological approach, the ability to â€Å"see† a face is a function of what? Incorrect A.seeing the object at it is in reality B.innate ideas of faces C.only the sense data of seeing the eyes, nose, mouth, skin, etc. D.sense data and the organizing categories of the mind Answer Key: D